Chadwell Heath Tesco Express, in High Road, will shut its doors for good on January 27.
The supermarket did not explain the reason behind the closure, but said that it will “continue to serve the local area” through nearby stores.
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A spokesperson for Tesco said: “We have taken the difficult decision to close our Chadwell Heath Express later this month.
“We continue to serve the local area through a number of nearby stores.”
They added that colleagues will continue to be consulted about this change, and will have the option to transfer to nearby stores.
The nearest Tesco stores are Goodmayes Rowallen Express, in Rowallen Parade, and Goodmayes Extra, in High Road, – both around a mile away.