The changes are due to engineering work and will affect trains from Monday to Friday (June 9 to June 13).
We have outlined and simplified the details so you can plan your journey this weekend.
Monday to Thursday (June 9 to June 12):
From 11.15pm until the end of service, accessible buses replace trains between Maidstone East and Ashford International.
The 10.25pm and 11.25pm trains from London Victoria to Ashford International services will be diverted between Otford and Ashford International to run via Sevenoaks.
Passengers should change at Otford for a connecting service to Maidstone East, and the onward replacement bus for stations to Ashford International.
The 12.25am train from London Victoria to Ashford International service will only run between Victoria and Maidstone East.
Trains between London Charing Cross or London Cannon Street and Maidstone East will stop additionally at Kemsing, East Malling and Barming.
Monday, Wednesday and Thursday (June 9, June 11, and June 12):
From 11.20pm until the end of service, accessible buses replace trains between Sittingbourne and Sheerness-on-Sea.
The 11.20pm and 11.50pm trains from London St Pancras International to Faversham services will be replaced by buses between Ebbsfleet International, Gillingham and Faversham calling at all stations except Higham, Newington and Teynham.
Tuesday, Wednesday and Thursday (June 10 to June 12):
The 12.27am train from London Victoria to Orpington service via Beckenham Junction will be diverted calling additionally at Denmark Hill and run non-stop between Denmark Hill and Shortlands.
Replacement buses will run between Denmark Hill and Orpington via Beckenham Junction calling at all stations except Brixton.
Passengers travelling to or from Brixton you can use London Underground between Victoria and Brixton at no extra cost.
Tuesday, Thursday and Friday (June 10, June 12, and June 13):
From 12.10am until the end of service, replacement buses will run between Gillingham and Faversham, calling at all stations except Teynham.
Connecting trains will run from Faversham to Ramsgate.
A replacement minibus will run between Sittingbourne and Teynham.
On Tuesday morning only the connecting train will not run between Faversham and Ramsgate, and the bus will be extended after Faversham to run to Ramsgate.
Wednesday and Thursday (June 11 and June 12):
The 11.07pm train from London St Pancras International to Ramsgate via Dover Priory service will be replaced by a bus between Dover Priory and Ramsgate calling at all stations except Thanet Parkway.
