The disruption comes as part of essential upgrade works on Barnes Bridge, which will see the Barnes to Kew Bridge section closed from August 23 to August 31 for strengthening and refurbishment.
During this period, buses will replace trains between the two stations.
Mark Goodall, Wessex route director at Network Rail, said: “There is never a good time to close the railway and the decision was taken to carry out these works to encompass the August bank holiday and finish before the schools started again as fewer people travel during that week.
“We appreciate it is unfortunate to have a line closure clashing with Brentford’s first home game of the Premier League season.
“Our works are planned over 12 months in advance and we are working with both clubs to ensure that fans are well aware ahead of the game.”
On the weekend of August 30 and 31, the closure will extend further, with replacement buses operating between Feltham and Barnes.
The works will affect fans travelling to Brentford’s Premier League fixture against Aston Villa, with warnings to plan ahead to avoid missing kick-off or facing delays on the journey home.
The project will involve removing and replacing the bridge’s middle girders, which play a critical role in supporting the tracks and trains by acting as the backbone of each span.
Wheel timbers on the outbound line will also be upgraded to new, longer-lasting, and eco-friendly materials designed to last 50 years, reducing future maintenance needs and environmental impact.
In addition to the bridge works, engineers will refurbish and strengthen the passenger footbridge at Chiswick station.
This will include the installation of new steelwork, removal of temporary scaffolding, water-jetting, and repainting.
The station footbridge has been closed since August 2 and will remain shut until September 15, with a diversion in place via Grove Park Bridge.
Peter Williams, customer and commercial director at South Western Railway, said: “These upgrades will help keep the railway reliable and resilient for many years to come, and we’re grateful to our customers for their patience while they are carried out.
“With rail replacement buses in place, we recommend checking before you travel and allowing some extra time for your journey.”
The current works follow a similar project completed last year between July 28 and August 2.
That scheme involved renewing and strengthening the steelwork pins on the bridge, which allowed the removal of a speed restriction and improved reliability for trains crossing the structure.
Wheel timbers were also replaced on the London-bound side during those improvements.
