The 75-year-old man, understood to have been a Bolivian national, has died today (February 28) after the incident at Seven Sisters Road, near the junction of Holloway Road.
Emergency services were called to the scene yesterday (February 27) at 11.35pm.
At the scene, the victim was found injured and taken to hospital in a critical condition.
However, the Metropolitan Police has since confirmed his death.
Formal identification and a post-mortem examination will be arranged in due course.
Three teenage girls – aged 14, 16 and 17 – were arrested originally on suspicion of grievous bodily harm before his death.
The force says this is now being reviewed after the update.
They remain in custody and enquiries are ongoing.
Superintendent Annmarie Cowley, one of the senior officers responsible for policing Islington, said: “I know this death will cause shock and very real concern in Holloway and the wider Islington area.
“I share those concerns, and I want to assure local people that a thorough police investigation is under way.
“There are additional police patrols in the local area. I urge local people to speak with these officers if you have any information or any concerns.
“The officers are there to support you, and they will be in and around Holloway throughout the weekend.”
DCI Paul Waller, Specialist Crime, is leading the murder investigation. He said: “Three people are in custody and specialists from across the Met have been working at pace since last night to establish exactly what happened.
“Every possible line of inquiry is being followed, and this includes forensic work and ongoing enquiries to identify all available CCTV.
“I am grateful to those members of the public who have contacted police already. I urge anyone who saw the incident but has yet to contact police to please get in touch and share what they know.”
Alternatively contact Crimestoppers anonymously on 0800 555 111.