The fire broke out at a ground floor maisonette in Selhurst Road just before 3.30pm yesterday (March 17).
Emergency services attended and a woman was rushed to hospital where she later died.
A small part of the front room was damaged by the blaze.
The incident was over just after 5pm.
A spokesperson for London Fire Brigade said: “A woman has died following a fire in South Norwood.
“Three fire engines and around 15 firefighters from Woodside, Croydon and Norbury fire stations were called to a fire at a ground floor maisonette in a semi-detached house on Selhurst Road.
“A small part of the front room was damaged by fire.
“One woman was treated on scene by London Ambulance Service and taken to hospital, where she later died.
“The Brigade’s 999 Control officers received a call alerting them to the fire at 1527, the incident was over by 1701.”
A spokesperson for London Ambulance Service said: “We were called at 3.30pm yesterday (17 March) to reports of a fire in Selhurst Road, South Norwood.
“We sent a number of resources to the scene including ambulance crews, an advanced paramedic and members of our Hazardous Area Response Team.
“We also dispatched London’s Air Ambulance.
“We treated two patients. We took one to a major trauma centre by road as a priority and the second patient was discharged at the scene.”