The Odeon in Camden, which has served the community for nearly 90 years, will close its doors on February 24, after opening in 1937.
The closure follows a mutual agreement between Odeon and its landlord.
Plans are in place to demolish the site and replace it with a new development.
An Odeon spokesperson told the Camden New Journal.
said: “Following talks with our landlord, we have come to a mutual agreement to close our Camden cinema.
“Supporting our local cinema team is our number one priority and we will be looking to secure jobs for as many of them as possible at our other cinema locations.”
The Odeon has operated as a five-screen multiplex and was previously known as the Gaumont cinema when it first opened on January 25, 1937.
It was briefly converted into a bingo hall in the early 1960s before reopening as an Odeon in 1964.
The surrounding site, including the neighbouring Mecca Bingo hall, is being redeveloped as part of the Camden Town Xchange project.
Secret Cinema Group had reportedly considered converting the bingo hall into a space for interactive events, but ultimately decided against the plan.
The wider scheme will include 244 student bedrooms and 49 affordable homes.
A cultural venue is also planned as part of the development, though it is not yet confirmed whether this will include a cinema or music venue.
