The closures, which cover motorways and major A-roads, are likely to cause inconvenience for motorists.
Two of them are expected to lead to delays of between 10 and 30 minutes.
National Highways is responsible for maintaining these major routes, so any closures on smaller roads will not be included in their schedule.
Commuters and local residents are urged to check their journeys in advance and allow extra travel time to avoid getting caught out by the planned works.
Here is a full list of upcoming closures:
• A282, from 10pm January 6 to 6am February 1, moderate delays (10-30 minutes): A282 northbound, junction 1a to West Tunnel West Tunnel, carriageway and slip road closure for tunnel works, diversion via National Highways roads.
• A282, from 10pm January 6 to 5am January 9, slight delays (under 10 minutes): A282 southbound, junction 31 to junction 1A, Lane closure for caballing works.
• A2, from 10pm January 7 to 6am January 8, slight delays (under 10 minutes): A2 eastbound, Darenth to Bean, Slip and lane closure for technology works.
• A2, from 11pm January 10 to 5am January 11, moderate delays (10-30 minutes): A2 westbound, junction Darenth Interchange link road to A282 northbound, junction 2, link road closure for urgent pothole repairs, diversion via National Highways network.
• A282, from 9.30pm January 11 to 5am January 12, slight delays (under 10 minutes): A282 northbound, Dartford Crossing, Tunnel closure for contraflow works, diversion via Highways England Network.
• A282, from 10pm January 11 to 5am January 12, slight delays (under 10 minutes): A282 northbound, Dartford Crossing West Tunnel, Tunnel closure for maintenance works, diversion via National Highways network.
• A282, from 10pm January 11 to 5am January 12, slight delays (under 10 minutes): A282 northbound and southbound, Dartford Crossing, QEII Bridge closure for maintenance, diversion via East Tunnel (contraflow).
• A282, from 10pm January 12 to 5am January 13, slight delays (under 10 minutes): A282 northbound, Dartford Crossing East Tunnel, Tunnel closure for maintenance works, diversion via National Highways network.
• A2, from 8pm January 13 to 6am January 16, slight delays (under 10 minutes): A2 both directions Ebbsfleet, Lane closure for drainage works.
• A282, from 9.30pm January 18 to 5am January 19, slight delays (under 10 minutes): A282 northbound, Dartford Crossing, Tunnel closure for contraflow works, diversion via Highways England Network.
• A282, from 10pm January 18 to 5am January 19, slight delays (under 10 minutes): A282 northbound, Dartford Crossing West Tunnel, Tunnel closure for maintenance works, diversion via National Highways network.
• A282, from 10pm January 19 to 5am January 20, slight delays (under 10 minutes): A282 northbound, Dartford Crossing East Tunnel, Tunnel closure for maintenance works, diversion via National Highways network.