Transport for London (TfL) is urging passengers to plan ahead for closures and reduced services between Friday, January 16 to Sunday, January 18.
The Piccadilly line will be fully closed over the weekend, with no service running on Saturday or Sunday, including the Night Tube on Friday night.
Replacement buses will be in operation and TfL advises using the Elizabeth line to reach Heathrow Airport.
The Elizabeth line will run a reduced service on Sunday between Paddington and Heathrow Terminal 4 and Maidenhead.
Two trains per hour will serve Acton Main Line, Hanwell, Heathrow Terminal 4, West Drayton, Langley, Slough, Burnham and Maidenhead, while West Ealing and Heathrow Terminals 2 and 3 will see four trains per hour. Ealing Broadway, Southall and Hayes & Harlington will have six trains per hour.
Cutty Sark DLR station remains closed until spring.
Early morning disruption is also expected on several London Overground routes on Friday, January 16.
The 5.29am Lioness line service from Watford Junction to Euston will begin instead at Willesden Junction at 6.04am.
There will be no southbound trains on the Mildmay line between Willesden Junction and Shepherd’s Bush before 6.15am.
On the Suffragette line, the 5.48am Barking Riverside to Gospel Oak service will not run, and the 6.24am train from Gospel Oak to Barking Riverside is also cancelled.
The Waterloo and City line remains closed throughout the weekend.
