Arne Slot’s side are closing in on the title, with the Reds sitting a whopping 13 points clear of second-placed Arsenal in the Premier League table.
Still, they will need to improve from their performance in Paris earlier this week. Liverpool beat PSG 1-0 but Slot admitted his team got lucky, after goalkeeper Alisson Becker produced a string of fine saves to deny the otherwise dominant hosts.
Saints, meanwhile, are rooted to the bottom of the league and have won just twice all season.
Here’s everything you need to know about the game.
Date, kick-off time and venue
Liverpool vs Southampton is scheduled for a 3pm GMT kick-off time on Saturday 8 March, 2025.
Anfield in Liverpool will host.
Where to watch Liverpool vs Southampton
TV channel and live stream: The game will not be broadcast in the UK as it takes place behind the 3pm blackout in Britain.
LIVE coverage: Follow all the action with Standard Sport’s dedicated match blog!
Liverpool vs Southampton team news
Liverpool will hope to welcome back Cody Gakpo for their game against Southampton
Getty Images
The Reds are also without Tyler Morton but Slot otherwise has a fully fit squad from which to choose.
Southampton will hope to have all of Adam Lallana, Jan Bednarek, Lesley Ugochukwu, James Bree and Kyle Walker-Peters available for the game.
Ryan Fraser, Ross Stewart and Juan Larios are all injured, however.
Liverpool vs Southampton prediction
Saints ran Liverpool pretty close in the reverse fixture earlier this season but appear to have regressed under Ivan Juric.
Anything other than a convincing Liverpool win would be a major surprise.
Head to head (h2h) history and results
Southampton vs Liverpool latest odds
Odds via Betfair and subject to change.