The Metropolitan Police were alerted to the crash in Hornchurch Road at 11.36pm on April 26.
Officers were dispatched to the scene with London Ambulance Service colleagues, where a 35-year-old man was found suffering from serious injuries.
He was treated at the scene before being taken to hospital.
His condition has been confirmed as life-threatening.
The crash is under investigation by detectives from the Serious Collision Investigation Unit, with enquiries underway to establish the circumstances surrounding the events.
A spokesperson for the Met said: “Police were called to Hornchurch Road RM11 at 23:36hrs on Saturday, 26 April following reports of a collision involving a car and a pedestrian.
“Officers attended the scene alongside the London Ambulance Service (LAS) who treated a 35-year-old man for serious injuries before taking him to hospital where he remains in a life-threatening [condition].
“Detectives from the Serious Collision Investigation Unit are working to establish the circumstances.”
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Anyone who witnessed the crash or who may have captured dash cam footage in the moments before or at the time of the incident should call police.
Call 101 or message @MetCC on X with the reference CAD 7897/26APR25.
Alternatively, those wishing to remain anonymous can contact Crimestoppers on 0800 555 111.
