The crash happened on the junction of Evelyn Street and Deptford High Street at around 8.30am today (November 13).
A number of resources were sent to the scene with an air ambulance among them.
One woman died from her injuries.
Photos from an eyewitness show a cordon in place sectioning off the road, with multiple police and ambulance vehicles at the scene of the crash.
Road closures are in place both ways between Abinger Grove and Deptford High Street, with congestion to Greenwich back over Creek Road Bridge.
Multiple bus routes are also currently on diversion.
A London Ambulance Service spokesperson said: “We were called at 8.22am today (13 November) to reports of a road traffic collision at the junction of Evelyn Street and Deptford High Street, SE8.
“We sent resources, including ambulance crews, paramedics in fast response cars, a paramedic from our hazardous area response team (HART) and an incident response officer.
“We also dispatched a trauma team in a car from London’s Air Ambulance.
“Very sadly, despite the best efforts of our crews, a woman was pronounced dead at the scene. We treated another patient and discharged them at the scene.”
We have contacted Metropolitan Police for further information.
