Essential maintenance work will see the west tunnels shut from 10pm on Saturday night (April 5).
Diversions will be in place via National Highways routes, but motorists are advised to plan ahead to avoid potential delays.
The closures, which affect both northbound and southbound traffic, are subject to change depending on weather conditions.
The Dartford Crossing, which connects Dartford in Kent to Thurrock in Essex via the A282, is a key transport route over the River Thames.
These closures are necessary for ongoing maintenance but may change depending on weather conditions.
Saturday, April 5 – Sunday, April 6
A282-Northbound
A282 northbound Dartford Crossing West Tunnel
Tunnel closure for maintenance works 10pm – 5am
Diversion via National Highways network