Essential maintenance work will see both the east and west tunnels shut at different times between Saturday, March 29, and Monday, March 31.
Diversions will be in place via National Highways routes, but motorists are advised to plan ahead to avoid potential delays.
The closures, which affect both northbound and southbound traffic, are subject to change depending on weather conditions.
The Dartford Crossing, which connects Dartford in Kent to Thurrock in Essex via the A282, is a key transport route over the River Thames.
These closures are necessary for ongoing maintenance but may change depending on weather conditions.
Saturday, March 29 – Sunday, March 30
A282-Northbound
A282 northbound Dartford Crossing West Tunnel.
Tunnel closure for maintenance works 10pm – 5am
Diversion via National Highways network
A282-Southbound
A282 Southbound to A2 eastbound fast link road carriageway closure
M25 Clockwise Jct 2 to Jct 3 Carriageway closure for joint replacement works 10pm – 5am Diversion via Local Authority Network
Sunday, March 30 – Monday, March 31
A282-Northbound
A282 northbound Dartford Crossing East Tunnel.
Tunnel closure for maintenance works 10pm – 5am
Diversion via National Highways network
A282-Southbound
A282 Southbound to A2 eastbound fast link road carriageway closure
M25 Clockwise Jct 2 to Jct 3 Carriageway closure for joint replacement works 10.30pm – 5.30am Diversion via Local Authority Network