The closures, set to occur between Wednesday, February 26, and Monday, March 3, will affect traffic on the A282 northbound.
There will be no closures at the Dartford Crossing on Monday, Tuesday and Friday night this week.
Diversions will be in place via National Highways roads, and motorists are advised to plan to avoid delays.
The Dartford Crossing is a vital road link over the River Thames in England, connecting Dartford in Kent to Thurrock in Essex via the A282.
These closures are crucial for ongoing maintenance and tunnel works, but they may be subject to change depending on weather conditions.
Wednesday, February 26 – Thursday, February 27
A282 Northbound
A282 Northbound East Tunnel closure
East Tunnel closure for tunnel works 11pm – 5.30am
Diversion via National Highways roads
Thursday, February 27 – Friday, February 28
A282 Northbound
A282 Northbound East Tunnel closure
East Tunnel closure for tunnel works 11pm – 5.30am
Diversion via National Highways roads
Saturday, March 1 – Sunday, March 2
A282 Northbound
A282 Northbound West Tunnel closure
West Tunnel closure for maintenance works 11pm – 5.30am
Diversion via National Highways roads
Sunday, March 2 – Monday, March 3
A282 Northbound
A282 Northbound East Tunnel closure
East Tunnel closure for maintenance works 11pm – 5.30am
Diversion via National Highways roads