The motor traffic-free zone will be trialled from the junction with Parkway and Kentish Town Road, in front of Camden Town Underground station, and up to the junction of Jamestown Road and Hawley Crescent.
It will be launched on Saturday, May 3 and marked with a street party on Monday, May 5, called The Big Street Party.
This will be the first event in a year-long cultural programme, called Camden at 60, which will run from 2025 to 2026.
Councillor Sabrina Francis, cabinet member for jobs, young people and culture, said: “Camden at 60: The Big Street Party is our amazing opportunity to show everyone how we have been able to reclaim this busy street, with its iconic markets, music venues, and businesses, and make the most out of this new public space.”
According to the council, the pedestrianisation trial will bring a “healthier, more vibrant Camden Town” and is backed by a £500,000 grant from the Mayor’s London Air Quality Fund.
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Councillor Adam Harrison, cabinet member for planning and a sustainable Camden, said: “At peak times there can be as many as 40,000 people on the high street, creating significant overcrowding and a stressful experience.
“So many people have asked why the high street is not already pedestrianised – now we are delivering on that call.”
Transport for London has also provided £130,000 for the development of the trial.
More than 70 per cent of people in a public consultation held last year said they supported pedestrianisation of the high street, according to the council.
The trial will include continual reviews and the collection of data to test the impact of the pedestrianisation, including feedback from residents, businesses, and visitors.
Consideration will then be given to the next steps, the council said, which could include the closure being made permanent.
More information about the trial, including the planned changes to bus routes, traffic routes and deliveries, can be found on the Camden High Street Commonplace website.