Some services will be diverted while some stations will not be called at, affecting journeys throughout the week and into the weekend.
Be sure to check out alternative routes, taking note of shuttle services and rail replacements in place.
Monday March 17 to Thursday March 20
Engineering works from 8.45pm between Fenchurch Street and Barking means that services on the Basildon line will be diverted to Liverpool Street after this time.
Trains will call at Stratford, but not Limehouse or West Ham.
The Rainham line faces the same disruption, but services will be extended to Shoeburyness.
Engineering work from 10.45pm between Barking and Upminster will also divert Basildon line services after this time via an alternative route.
Trains will not call at Upminster, West Horndon, Laindon and Basildon.
The same works will impact the Ockendon line, with a train shuttle running between Upminster and Grays via Ockendon and Chafford Hundred after 8.45pm.
Friday March 21 to Saturday March 22
No planned engineering works.
Sunday March 23
Engineering works are planned until 2.25pm between Liverpool Street and Barking, and between Fenchurch Street and Grays via Rainham.
Basildon line services will start and terminate at Upminster, and will not call at Barking or further stations.
The same alternative route will be in effect on the Ockendon line.
No trains will run on the Rainham line until engineering works have finished.