70 firefighters in 10 fire engines tackled the blaze in Electric Avenue around 9.40am today (July 7).
A storage area in an alleyway behind a mixed-use building was burning sending large amounts of smoke into the sky.
Brixton Underground station was closed and the Victoria line suspended while Electric Avenue, Brixton Road and Atlantic Road were closed in full or part.
There were no reports of injuries but reported being evacuated from their buildings.
LIVE updates as 70 firefighters tackle blaze on well-known street in Brixton
After flames spread into the roof above the storage area, they were finally brought under control around 1.10pm.
Meanwhile, fire crews remain on the scene to damp down hotspots and road and rail closures remain in place.
The Brigade received 25 calls about the highly visible fire with crews from Brixton, Peckham, Lambeth, West Norwood and surrounding fire stations being sent to the scene.
A 32-metre turntable ladder used as an observation tower to provide a better view of the fire and as a water tower to help extinguish the flames from height.
