The London Ambulance Service was called at 6.56am this morning (January 10) with reports of the incident on the A102 Woolwich slip road onto the Blackwall Tunnel Approach.
A fleet of paramedic resources were sent to the scene with officers from the Metropolitan Police, where it was confirmed that a lorry had crashed.
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The driver, a man, was treated at the scene before being taken to hospital where his condition is unknown.
A spokesperson for the Met has warned that road closures remain in place whilst the road is cleared.
There have been no arrests and enquiries into the circumstances are ongoing.