Orhan Ekren, 48, was last seen in the vicinity of Camden Market, near Camden Lock, at around 10.40pm on November 26.
He was wearing dark clothing and carrying a dark backpack, which was found near the canal the following day.
Orhan is of Turkish heritage and lives with his family in Milton Keynes.
Police are particularly keen to speak to people that live in the Camden area, or who might have been in the area at the time, or that have a barge moored on the canal.
If you have seen Orhan or have any information on his whereabouts call 999 and quote reference 01/1137478/24.
