The work will affect trains on Saturday (January 18) and Sunday (January 19).
We have compiled all the details on these works so that you can plan your journey this weekend.
Engineering work is taking place between London Charing Cross, Cannon Street and New Cross, closing all lines.
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No trains will run to or from London Charing Cross, Waterloo East or London Cannon Street.
New Cross and St Johns will also be closed all weekend.
Trains on most of these routes are diverted to run to or from London Victoria.
A significantly reduced service will run from London Bridge:
Two trains per hour running between London Bridge and Hastings via East Croydon or Redhill
Two trains per hour between London Bridge and Dartford via Greenwich.
Saturday (January 18):
Paddock Wood Line: Trains between London Charing Cross and Ramsgate or Dover Priory via Tonbridge will be diverted to run to and from London Victoria.
Hastings Line: Trains between London Charing Cross and Hastings will run to and from London Bridge and run non-stop between London Bridge and Tonbridge by an alternative route.
Trains which usually only run between London Charing Cross and Tunbridge Wells will not run.
Maidstone East line: Trains between London Charing Cross and Maidstone East will not run, but trains between London Victoria and Ashford International via Maidstone East and will be retimed.
A reduced service of one train per hour will run between London and Maidstone East.
Bexleyheath Line: Services between London Cannon Street and Slade Green, and London Charing Cross and Dartford via Bexleyheath will not run.
Services between London Victoria and Dartford via Bexleyheath will run normally.
A reduced service of two trains per hour will run between London and Barnehurst via Bexleyheath.
Woolwich Arsenal Line: Trains between London Cannon Street and Dartford via Woolwich and trains between London Cannon Street and Slade Green via Greenwich will not run.
Additional trains will run between London Bridge and Dartford via Greenwich.
A reduced service of two trains per hour will run between London and Slade Green via Woolwich.
Grove Park Line: Trains between London Charing Cross and Sevenoaks will be diverted to run to or from London Victoria.
Services between London Cannon Street and Orpington will not run.
A reduced service of two trains per hour will run between London and Orpington via Grove Park.
Sidcup Line: Trains between London Charing Cross and Gravesend will run to and from London Victoria.
A reduced service of two trains each hour will run between London and Dartford via Sidcup.
Hayes Line: Trains between London Charing Cross and Hayes will run to and from London Victoria.
A reduced service of two trains each hour will run between London and Hayes.
The last three trains of the day from London Victoria to Hayes will be diverted after New Beckenham to run to Orpington calling additionally at Beckenham Junction.
Passengers should change at Beckenham Junction for a replacement bus calling at all stations to Hayes.
Sunday (January 19):
Paddock Wood Line: Trains between London Charing Cross and Ramsgate or Dover Priory via Tonbridge will be diverted to run to and from London Victoria.
Hastings Line: Trains between London Charing Cross and Hastings will run to and from London Bridge and run nonstop between London Bridge and Tonbridge by an alternative route.
Sole Street line: Trains between London Victoria and Dover Priory via Demark Hill will be retimed and only run between London Victoria and Gillingham because of further engineering work.
Maidstone East line: Trains between London Victoria and Maidstone East will be retimed.
Bexleyheath Line: Services between London Cannon Street and Slade Green via Bexleyheath will not run.
Services between London Victoria and Dartford via Bexleyheath will run normally.
Woolwich Line: Trains between London Cannon Street and Slade Green via Greenwich will not run.
Additional trains will run between London Bridge and Dartford via Greenwich.
Grove Park Line: Trains between London Charing Cross and Sevenoaks will be diverted to run to and from London Victoria
Sidcup Line: Trains between London Charing Cross and Gravesend will run to and from London Victoria.
A reduced service of two trains per hour will run between London and Dartford via Sidcup.
Hayes Line: Trains between London Charing Cross and Hayes will run to and from London Victoria
Replacement buses will run between Lewisham and Greenwich calling at St Johns and New Cross.