The events, organised by charity Access Sport in partnership with several organisations, will take place on April 7, 9, 15, and 17.
Activities include tennis, dance, sensory football, taekwondo, athletics, and adaptive cycling.
All activities will run from 10am to 12pm, and participants must be accompanied by a parent or carer.
Matthew Houghton, GLL’s community sports manager in the borough, said: “We’re delighted to be hosting such a groundbreaking and inclusive event supporting some of south London’s most vulnerable young people.
“It promises to be a lot of fun.
“We’re proud to be working with Access Sport, Lewisham Council, and other local partners from across the London Borough of Lewisham.”
The events are being held in partnership with the London Borough of Lewisham and charitable social enterprise GLL.
To attend the event, young people must be registered.
For more information, email Disability.Inclusion@AccessSport.org.uk or call 0207 993 9883.