These are part of a planned maintenance to boost road safety and infrastructure.
Drivers are forewarned that diversions and delays might accompany these crucial works.
National Highways maintains motorways and major A-roads, so smaller road shutdowns are not on its schedule.
The A2 serves as a crucial link connecting Dover to the heart of London.
It spans nearly 72 miles from Borough in the capital and finishes at the Dover Docks.
Monday, July 21
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A2 eastbound Cobham entry and exit slip roads will be closed from 8pm to 6am for maintenance between Tolgate and M2 Junction 2.
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A21 both directions between Bodiam Road and Northbridge Street roundabout will be shut from 8pm to 6am for surface works.
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A21 southbound Vauxhall exit slip road will be closed from 8pm to 6am for maintenance from Quarry Hill Interchange.
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A282 southbound link road to A2 eastbound will be closed from 10pm to 6am for surface works between Bexleyheath and Pepperhill.
Tuesday, July 22
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A2 eastbound Coldharbour Lane entry and exit slip roads will be shut from 8pm to 6am for maintenance from Bridge to Coldharbour Lane.
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A21 both directions between Bodiam Road and Northbridge Street roundabout will be closed again from 8pm to 6am for ongoing surface works.
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A282 southbound to A2 eastbound link road remains shut from 10pm to 6am for resurfacing.
Wednesday, July 23
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A21 both directions continue to face closures from Bodiam Road to Northbridge Street roundabout between 8pm and 6am.
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A21 northbound carriageway from Vauxhall Lane to Morleys Road roundabout will be shut from 8pm to 6am for surface repairs.
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A282 southbound link road to A2 eastbound will be shut from 10pm to 6am.
Thursday, July 24
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A2 eastbound entry and exit slip roads at Womensworld and Wick Lane will be shut from 8pm to 6am for maintenance.
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A21 both directions continue closures from Bodiam Road to Northbridge Street roundabout, 8pm to 6am.
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A21 northbound closure from Vauxhall Lane to Morleys Road roundabout continues 8pm to 6am.
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A282 southbound to A2 eastbound link road shut again from 10pm to 6am.
Friday, July 25
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A2 eastbound entry and exit slip roads at Singlewell and Tollgate will be closed from 8pm to 6am.
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A21 both directions and northbound carriageway from Bodiam Road and Vauxhall Lane to Morleys Road roundabout closed from 8pm to 6am.
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A282 southbound link to A2 eastbound will again be closed from 10pm to 6am.
Saturday, July 26
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A282 northbound Dartford Crossing West Tunnel will be closed from 10pm to 5am for maintenance. A diversion will be in place.
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A282 southbound Jct 1A entry slip road shut from 9pm to 8am for waterproofing work.
Sunday, July 27
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A2 eastbound Pepperhill entry slip road will be closed from 8pm to 4am for maintenance.
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A282 northbound Dartford Crossing East Tunnel will be closed from 10pm to 5am. Vehicles over 4.8m will not have access.
