The emergency services were called to Holland Road at around 3pm yesterday (January 14).
A woman in her 70s was found fighting for her life and later died at the scene.
No arrests have been made and a police investigation is underway.
The incident happened on a popular route taken by school children to Kensington Olympia Overground station.
Officers are appealing for anyone with any information to get in touch.
A London Ambulance Service spokesperson said: “We were called at 2.58pm today (14 January) to reports of a road traffic collision on Holland Road, W14.
“We sent resources to the scene including ambulance crews, an incident response officer and a clinical team manager. We also dispatched London’s Air Ambulance.
“Very sadly, despite the best efforts of our crews, a woman was pronounced dead at the scene.”
A spokesperson for the Met Police said: “Police were called by the London Ambulance Service at 15.01hrs on Wednesday, 14 January following reports of a collision between a lorry and a pedestrian on Holland Road, Kensington.
“A woman in her 70s was found with life-threatening injuries. She was sadly later pronounced dead at the scene.
“No arrests have been made and enquiries continue.
“If you have information or dashcam footage that could help police, please call 101 quoting CAD 4823/14Jan.”
