Thames Valley Police was called to the A4 Colnbrook Bypass, also known as Lakeside Road, around midday on August 31 following a crash between a red Triumph motorcycle and a lorry trailer.
A red Triumph motorcycle had crashed with a lorry trailer and the biker, a 47-year-old man from Ruislip, died at the scene.
There have been no arrests and officers are appealing to the public for more information.
Investigating officer PC Mark Dunne from the Roads Policing Unit said: “Firstly, I want to offer my deepest condolences to the family of the man who sadly died in this collision.
“I am appealing to anyone who was in the area at the time to please check their dash-cam footage, in case they captured the collision or the moments leading up to the collision.
“Anyone with information should call 101 or make an online report, via our website, quoting reference number 43250445296.
“If you do not wish to speak to the police you can contact the independent charity Crimestoppers who will take your information 100% anonymously.
“You can call them on 0800 555 111.”
