The incident happened in Old Kent Road in Bermondsey at around 10.45pm last night (August 27).
Paramedics arrived with a team from London’s Air Ambulance and treated three people for stab wounds.
All three were taken to hospital where their condition is not yet known.
It is not yet known if there have been any arrests.
LIVE as major road closed overnight after triple stabbing in south east London
Old Kent Road is closed between Glengall Road and Canal Bridge Interchange due to what was reported as a crash.
A London Ambulance Service spokesperson said: “We were called at 10.44pm on Wednesday 27 August to reports of a stabbing on Old Kent Road, SE1.
“We sent resources to the scene, including ambulance crews, an advanced paramedic, a paramedic from our tactical response unit and an incident response officer.
“We also dispatched a trauma team from London’s Air Ambulance, which consists of a doctor and a paramedic in a car.
“We treated three patients for stab wounds and took them to major trauma centres.”
Met Police has been contacted for comment.
This is a breaking news story. More to follow.