The London Ambulance Service was sent with the air ambulance to Seville Street just before 9.30pm yesterday (July 9).
Officers arrived to find a man who had been stabbed and he later died at the scene.
A crime scene was put in place outside the Park Tower Hotel and Casino, directly across the road fro, the Harvey Nichols department store.
Those closest to the victim have been told and are now being supported by specialist officers.
There have been no arrests but an investigation is underway.
Superintendent Owen Renowden, who leads policing in Kensington and Chelsea, said: “Our thoughts are with the victim’s loved ones following the shocking events that took place last night.
“Detectives from the Specialist Crime Command, supported by local officers, are working at pace to establish the circumstances of what happened.
“We are aware of reports that this incident was a robbery.
“Although this is an active line of enquiry, we are keeping an open mind about all possible motives and the exact circumstances are still to be determined.
“We understand the impact this incident will have on the local community and you will see extra officers in the area to help answer any questions or concerns.”
Please call police on 101 referencing CAD 8521/09JUL if you were a witness or have any information which might help.
You can also contact Crimestoppers anonymously on 0800 555 111 or on its website.
