A forensic tent has been put up at Chingford Mount Road after the fatal knife attack on Sunday (July 6).
Emergency services were called at 9.11pm to reports of the stabbing.
However, a 26-year-old man was pronounced dead at the scene.
No arrests have been made at this stage, but police and forensics continue to investigate.
The road closure will be in place for some time, the Metropolitan Police said.
The man’s next-of-kin are aware and are being supported by specialist officers.
Chief Superintendent Dan Card, who leads policing in the local area, said: “We are deeply saddened by the events that took place last night and our thoughts remain with the man’s family at this hugely difficult time.
“Detectives are working hard to establish the circumstances of what happened yesterday evening.
“We understand the impact this incident will have on the local community and officers are being deployed on reassurance patrols to help answer any questions or concerns.”
Anyone with information is asked to call police on 101 quoting reference CAD7174/6July.
Alternatively, to stay anonymous contact Crimestoppers on 0800 555 111.
