Police were called to Great Cambridge Road yesterday (June 26) at 8.45pm to reports of gunshots fired.
Medics treated an 18-year-old at the scene before taking him to hospital, where he died.
His family has been informed and they are currently receiving support from specialist officers.
Police are treating this as an isolated incident, but there will be an increased presence of officers in the area in the next few days.
A crime scene also remains in place and the road is closed while enquiries are carried out.
No arrests have been made at this time.
Detective Chief Superintendent Caroline Haines who leads policing in Enfield has said: “I am saddened to hear that a young man lost his life last night. My thoughts are with his family and friends who will be processing this news today.
“We want to reassure the community that this appears to be an isolated incident and a thorough investigation is underway.
“The safety of the public remains one of our highest priorities. We are working tirelessly to ensure that those responsible are held to account.
“I would like to send my thanks to the community now, as there will be an increased police presence while we carry out enquiries over the next few days. Your patience is greatly appreciated.
“An incident like this is deeply concerning to members of the community, and we recognise that some may feel effected. Please do approach any of our officers who are in the local area, they will be happy to provide support to you.”
Anyone with information is asked to call police on 101 quoting CAD8393/26JUNE. Alternatively contact Crimestoppers anonymously on 0800 555 111.