The incident happened at an address in Ayley Croft at around 7pm yesterday (April 19).
Officers and London Ambulance Service crews attended and found a woman who had been stabbed.
She was pronounced dead at the scene shortly after.
Her next of kin has been informed and is being supported by specialist officers.
No arrests have been made as police enquiries continue.
Detective Chief Inspector Neil John, from the Metropolitan Police who is leading the investigation, said: “Our thoughts are with the victim’s family at this difficult time.
“As our investigation continues there will be an increased police presence in the area, and a crime scene remains in place.
“We understand this will be very distressing to the local community and anyone who has concerns can speak to local officers.
“To aid us with our investigation, I would like to appeal to the public for information.
“We are particularly interested in talking to anyone who was driving through Ayley Croft between 6.30pm and 7.30pm that may have dashcam footage.
“To share footage or any other information, no matter how insignificant you believe it may be, please call 101, referencing CAD 5741/19APRIL.”
Detective Chief Superintendent Caroline Haines, Borough Commander who oversees policing for Enfield, said: “We understand the concern that this will cause local residents. Neighbourhood officers will be working alongside specialist officers in the coming days to progress the investigation and support the local community.
“Please contact officers if you have any information or any concerns.”
Anyone with information is urged to contact police by calling 101 quoting the reference 5741/19APRIL.
Alternatively, to remain anonymous you can call Crimestoppers on 0800 555 111.
