Officers were called to reports of a stabbing in Kingsbury Road just before 1.50pm today (April 17).
London Ambulance Service also attended and a man was found suffering a number of stab wounds.
He was taken to hospital for treatment where his injuries were assessed as potentially life-changing.
No arrests have been made as police enquiries continue.
A spokesperson for Metropolitan Police said: “Police were called at 1.49pm on Thursday, 17 April following reports of stabbing in Colindale.
“Officers joined London Ambulance Service at the scene in Kingsbury Road, where a man in his 20’s had been stabbed several times.
“His injuries have been deemed to be non-life-threatening, but may be life-changing.
“He was taken to hospital for treatment. No arrests have been made as of yet. Enquiries are ongoing.”
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The London Ambulance Service has confirmed that the first paramedic arrived within three minutes of the report coming in.
If you have any information which may help, please call police on 101 with the reference 3936/17Apr.
You can also provide information anonymously to the independent charity Crimestoppers on 0800 555 111.