These are part of a planned maintenance to boost road safety and infrastructure.
Drivers are forewarned that diversions and delays might accompany these crucial works.
National Highways maintains motorways and major A-roads, so smaller road shutdowns are not on its schedule.
The A2 serves as a crucial link connecting Dover to the heart of London. It spans nearly 72 miles from Borough in the capital and finishes at the Dover Docks.
Here are the planned closures for the rest of this week:
Tuesday, March 25
- A2 eastbound closure from Ebbsfleet Eastern Roundabout to Hall Road slip road, 8pm to 6am.
- A21 both directions closed between A2100 and Westfield Lane, 8pm to 6am.
- A21 southbound closed from Pembury to Kippings Cross, 8pm to 6am.
- A21 northbound closure from Morleys Road to A25 Westerham Road, 8pm to 6am.
- A282 northbound Dartford Crossing East Tunnel closure, 10pm to 5.30am.
Wednesday, March 26
- A2 eastbound closure from Ebbsfleet Eastern Roundabout to Hall Road slip road, 8pm to 6am.
- A21 both directions closed between A2100 and Westfield Lane, 8pm to 6am.
- A21 southbound Quarry Hill exit slip road closure, 8pm to 6am.
- A21 northbound closure from Morleys Road to A25 Westerham Road, 8pm to 6am.
- A282 northbound Dartford Crossing East Tunnel closure, 10pm to 5.30am.
Thursday, March 27
- A2 eastbound closures from Brenley Corner to Wincheap and from Ebbsfleet Eastern Roundabout to Hall Road slip road, 8pm to 6am.
- A21 both directions closed between A2100 and Westfield Lane, 8pm to 6am.
- A21 southbound Quarry Hill exit slip road closure, 8pm to 6am.
- A282 northbound Dartford Crossing East Tunnel closure, 10pm to 5.30am.
Friday, March 28
- A2 eastbound closures from Brenley Corner to Wincheap and from Ebbsfleet Eastern Roundabout to Hall Road slip road, 8pm to 6am.
- A21 both directions closed between A2100 and Westfield Lane, 8pm to 6am.
- A21 southbound Quarry Hill exit slip road closure, 8pm to 6am.
Saturday, March 29
- A2 eastbound closures from Brenley Corner to Wincheap and from Ebbsfleet Eastern Roundabout to Hall Road slip road, 8pm to 6am.
- A2 westbound to M25 clockwise entry fast slip road closure, 10pm to 5am.
- A21 both directions closed from Johns Cross to Westfield Lane, 8pm to 6am.
- A282 northbound Dartford Crossing West Tunnel closure, 10pm to 5am.
- A282 southbound to A2 eastbound fast link road closure, 10pm to 5am.
Sunday, March 30
- A2 eastbound closures from Brenley Corner to Wincheap and from Ebbsfleet Eastern Roundabout to Hall Road slip road, 8pm to 6am.
- A2 westbound to M25 clockwise entry fast slip road closure, 10.30pm to 5.30am.
- A21 both directions closed between A2100 and Westfield Lane, 8pm to 6am.
- A282 northbound Dartford Crossing East Tunnel closure, 10pm to 5am.
- A282 southbound to A2 eastbound fast link road closure, 10.30pm to 5.30am.
