The motorway will close for the final time as part of a National Highways improvement project between 9pm on Friday, March 21 and 5.30am on Monday, March 24.
This is to allow for the “safe” removal of a bridge following the completion of an upgrade at Junction 10 last month.
This closure will be the fifth and final part of the improvement project, which aims to reduce congestion, improve traffic flow, and provide safer journeys.
Jonathan Wade, senior project manager, said: “We are now on the home straight of this complex project and we are pleased to say this is the last time the M25 will be closed over a full weekend.
“Two weeks ago, when we last closed the motorway, we saw higher levels of traffic than in the previous three closures and it caused significant disruption and delays in local areas.
“We obviously want people to spend time enjoying themselves, we don’t want anyone to be stuck in long traffic jams.
“If you’re travelling around Surrey this weekend, I’d again urge you to only use the motorway and surrounding areas if your journey is absolutely necessary.
“Please allow extra time and use alternative routes where possible, and make sure you follow our official diversions, and not information from sat-navs.”
This comes after a “notable increase in traffic” during the last closure, which coincided with the first sunny weekend of the year.
Those travelling clockwise will be diverted onto the A3 northbound at junction 10 and then the A245 and A320 before rejoining the M25 at junction 11.
Those going in the opposite direction will take the A320 southbound at junction 11, before heading onto the A245 and the A3, rejoining the motorway at junction 10.
The junction 10 improvement scheme will see an increase in the number of lanes to make journeys safer and improve traffic flow.
It will also make it easier and safer to enter and exit the M25, provide safer entry roads for Wisley, Pyrford, Old Byfleet and RHS Garden Wisley, and will reduce the pollution caused by traffic jams.
This weekend marks the final weekend closure of the M25, though work on the A3 will continue over the coming months.
