The popular attraction will be shut from Monday, March 17, to Wednesday, March 26, reopening to the public on Thursday, March 27.
The maintenance work will be carried out by Doppelmayr, the cable car’s maintainer.
This year, the planned work will involve the replacement and renewal of essential components on the tower assemblies.
Trish Ashton, TfL’s director of rail and sponsored services, said: “More than ten years after opening, the IFS Cloud Cable Car continues to be a success with Londoners and visitors to the capital.
“We know that our customers love the unique experience and spectacular views the cable car offers.
“Our planned annual maintenance ensures that we can continue to run a safe and reliable service for our customers all year round.
“We apologise for any disruption this causes.
“However, by carrying out this vital work now we will minimise the need for any future disruptions this year.”
While the closure is in place, the nearest alternative public transport is North Greenwich Tube station for the Jubilee line on the south side of the river and Royal Victoria DLR station on the north side.
Both are a short walk away from the IFS Cloud Cable Car.
Bus services are available from North Greenwich bus station and Royal Victoria.
River services also operate from North Greenwich Pier next to the IFS Cloud Greenwich Peninsula Terminal.
The cable car also links with the new Elizabeth line station at Custom House.
