The incident happened in Tiverton Road near Frogwell Close at 4.55am today (January 13).
A 20-year-old man was arrested at the scene, while a 23-year-old woman and two men, 20 and 23, were arrested nearby.
Officers and London Ambulance Service crews attended, however, the man was pronounced dead shortly after.
While officers believe they know his identity, enquiries are still ongoing to inform his next of kin.
The road was shut off by police as eyewitnesses claim “two raids” took place near the estate after the knife attack.
Part of the estate remains closed as investigations are ongoing.
Detective Chief Superintendent, Caroline Haines from the North Area Command Unit responsible for policing in Haringey, said:
“We are saddened to hear about this morning’s tragic incident and are working to ensure the man’s family are informed and supported by specialist officers as soon as possible.
“Our officers acted swiftly and arrested four people on suspicion of murder who are now in custody. Local residents can expect to see more police in the area while we carry our enquiries and as part of extra patrols.
“We are also urging anyone who may have seen or heard anything related to this incident to contact us, you may have information vital to our investigation.”
Anyone with information is asked to call police on 101 quoting 809/13Jan. Alternatively, contact Crimestoppers anonymously on 0800 555 111.