The V&A East Museum, in Queen Elizabeth Olympic Park, is opening on Saturday, April 18.
Historical pieces, such as Italian Renaissance paintings, 16th-century scent cases, and an 18th-century Spitalfields silk dress, will be displayed.
A large sculpture by Thomas J Price, titled A Place Beyond, will greet visitors at the entrance.
The first “landmark” exhibition, The Music Is Black: A British Story, will open with the museum, celebrating Black British music and culture through the years.
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Gus Casely-Hayford, V&A East director, said: “In today’s world where we’re facing down challenges from the climate crisis to increasing polarisation, museums and the creative industries have a vital role in bringing people together.
“They celebrate communities, sparking conversations and spotlighting the many ways that global artists, designers and makers are using their creativity to change the world for the better.
“We have created V&A East Museum with and for our audiences, as a welcoming space for all, embedded in east London and with a global outlook, that reflects the multiculturalism of this incredible place that has been the beating heart of creativity for centuries.”
