The 22-year-old has been battling more injury issues having withdrawn from the ASB Classic in Auckland due to a back problem.
But she has declared herself fit to play and will take on No26 seed Alexandrova.
“I’ve been feeling good,” Raducanu said ahead of her first-round match. “I think the last 10 days I’ve had a positive block of training.
“Coming back on the court, adapting to the conditions here, has been good for me. Now I feel good and I feel ready to give it my best here.
“It’s a tricky draw, of course. Being unseeded, you can play any top opponent. She’s a player with a lot of experience. I guess I’m coming in with the underdog mentality. She’s been in this situation many more times than I have.”
How to watch Emma Raducanu at Australian Open 2025
In the UK, Raducanu vs Alexandrova takes place in the early hours of Tuesday January 14, 2025.
TV channel: In the UK, the Australian Open will be broadcast live on Eurosport. Coverage starts at 12am GMT and will run through to the end of play at around 2.30am BST
Live stream: Subscribers can also stream the action online on the Eurosport website or with the Discovery+ app.