Ange Postecoglou’s side, however, are in dire form and were beaten 2-1 at home by Newcastle on Saturday to make it six defeats in seven, including a 6-3 home loss to the Reds last month.
Sitting pretty in the Premier League and the Champions League, Arne Slot’s side were held a dramatic 2-2 draw with United on Sunday.
Here’s everything you need to know about the game.
Date, kick-off time and venue
The Tottenham Hotspur Stadium in London will host.
Where to watch Tottenham vs Liverpool
TV channel: The game will be broadcast on Sky Sports Main Event, Sky Sports Premier League and Sky Sports Ultra HDR. Coverage starts at 7pm.
Live stream: Subscribers will be able to watch on a live stream via the Sky Go app.
LIVE coverage: Follow all the action with Standard Sport’s dedicated match blog!
Tottenham vs Liverpool team news
Spurs remain without a raft of key first-team players. All of Destiny Udogie, Micky van de Ven, Cristian Romero, Ben Davies, Wilson Odobert and Richarlison expected to miss out.
Radu Dragusin will be fit for the game despite coming off at half-time against Newcastle, while Mikey Moore could be on the bench.
Liverpool will be without Joe Gomez. Dominik Szoboszlai missed the United game due to illness and remains a doubt.
Liverpool will hope to welcome back Dominik Szoboszlai
Fabrizio Carabelli/PA Wire
Tottenham vs Liverpool prediction
Spurs’ injury woes have only worsened since, but have also proven they can breach the Reds’ backline. They will hope to still be in the tie come full-time tonight.
Head to head (h2h) history and results
Tottenham vs Liverpool latest odds
Odds via Betfair and subject to change.