It has been a tough two weeks for the Gunners, who have seen their Premier League title hopes again seemingly go up in smoke after frustrating dropped points, this time against West Ham and Nottingham Forest, as Liverpool moved 13 points clear at the top of the table.
It leaves the Champions League as effectively Arsenal’s only hope of ending the season with some silverware, though it is a daunting task lying in wait.
Should the Gunners, lacking in confidence and depleted in attack, find a way past PSV, they will face either Real Madrid or Atletico Madrid in the quarter-finals, with Liverpool and PSG also on the same side of the draw.
PSV finished 14th in the league phase of this competition, before edging past Juventus in the knockout round play-off.

Arsenal earned a bye straight through to the Champions League last-16
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Date, kick-off time and venue
PSV vs Arsenal is scheduled for an 8pm GMT kick-off time tonight, Tuesday, March 4 2025.
The Philips Stadion in Eindhoven will host.
Where to watch PSV vs Arsenal
TV channel: The game will be broadcast on Amazon Prime Video. Coverage starts at 6.30pm GMT ahead of an 8pm kick-off.
Live stream: Subscribers will be able to watch on the Amazon Prime website or app.
LIVE coverage: Follow all the action with Standard Sport’s dedicated match blog, featuring expert analysis from Simon Collings at the ground.
Former Arsenal striker Lucas Perez recently signed for PSV as a free agent, but he was not registered in the club’s Champions League squad and is therefore ineligible.
Malik Tillman, Ricardo Pepi and Esmir Bajraktarevic are all injury concerns for the hosts.
Mikel Merino is likely to continue up front, unless Raheem Sterling comes into the side. Ben White is in contention to make his first start since November, though Jurrien Timber, Riccardo Calafiori and Myles Lewis-Skelly are all available too.

Double blow: Gabriel Martinelli and Bukayo Saka are still out with hamstring injuries
Arsenal FC via Getty Images
PSV vs Arsenal prediction
It is difficult to see where the Arsenal goals are going to come from.
They remain a threat from set-pieces but the Gunners have been largely unthreatening in open play in recent weeks and it means they are unlikely to enjoy too many comfortable nights.
Arsenal’s defence remains superb and Arteta’s side should still be capable of taking at least a draw back to the Emirates for the second leg.
Head to head (h2h) history and results
PSV vs Arsenal latest odds
Odds via Betfair and subject to change.