The Briton lost her WBO welterweight world title in September after a majority decision defeat to Mayer, with that coming just hours after she was attacked with a can of red paint as she left her hotel.
Ryan suggested in the aftermath of the fight that she should have pulled out as a result of the attack, in what was a second frustrating bout in the United States for the 31-year-old.
In 2023, Ryan believed she had done enough to beat Jessica McCaskill and become unified world champion, but the fight was scored a draw and the American kept hold of her WBA and WBC titles.
Those straps are now held by Lauren Price, after her wins over McCaskill and Natasha Jonas, and the Welshwoman will be eyeing an undisputed showdown with whoever comes out on top on Saturday night.
Mayer is now a two-weight world champion, with her victory over Ryan adding to the super-featherweight titles she held earlier in her career. The 34-year-old was beaten at the start of last year when challenging for Jonas’ IBF belt at welterweight, but climbed to the top of the division at the second time of asking.
Mikaela Mayer beat Sandy Ryan on points in September to win the WBO welterweight world title
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Mayer vs Ryan 2 fight date and venue
Mayer vs Ryan takes place on Saturday March 29, 2025 at the Fontainebleau in Las Vegas, Nevada.
Mayer vs Ryan 2 fight time and ring walks
The undercard is due to get underway at 12am GMT, with television coverage beginning at midnight.
Ring walks for the main event are expected at approximately 3am in the early hours of Sunday UK time, though as ever those timings are subject to change.
How to watch Mayer vs Ryan 2
TV channel: In the UK, Mayer vs Ryan 2 is being shown live on Sky Sports Main Event and Sky Sports Action.
Live stream: Sky Sports subscribers can also watch the action live online via the SkyGo app.
Mayer vs Ryan 2 undercard
Mikaela Mayer vs Sandy Ryan
Brian Norman Jr. vs Derrieck Cuevas
Bruce Carrington vs Jose Enrique Vivas
Emiliano Vargas vs Giovannie Gonzalez
Troy Isley vs Etoundi William
Delante Johnson vs Kendo Castaneda
Dedrick Crocklem vs Dionne Ruvalcaba
Mayer vs Ryan 2 prediction
There was very little to split Mayer and Ryan in the first fight and another tight clash is expected here.
Ryan has spoken of how much the paint attack impacted her, saying she was “fighting off empty”, and that will encourage her heading into the rematch, considering just how competitive the first fight still was.
The Briton made a fairly slow start in September and cannot afford a repeat here, with Mayer’s speed helping her establish control. Ryan did grow into the bout and the left hook was a particular weapon for her, with that shot surely a key part of her gameplan this time.
There had been questions over how Mayer would fare at welterweight, having stepped all the way up from super-featherweight, but she answered those and appeared to carry real power in her right hand.
Ryan will need to force the pace more from the first bell and get Mayer on the back foot. If she can do that, and avoid any fight-week distractions, she could well bring the WBO title back to the UK.
Mayer vs Ryan 2 weigh-in results
The fighters will take to the scales on Friday – check back in then for the results!
Mayer to win on points or by decision: 11/10
Mayer to win by knockout, technical knockout or disqualification: 11/1
Ryan to win on points or by decision: 6/5
Ryan to win by knockout, technical knockout or disqualification: 8/1
Odds via Betfair (subject to change).
