Six months on from their contentious first clash on the Artur Beterbiev-Dmitry Bivol undercard in Riyadh, the British pair will settle their rivalry in a headline bout at bp pulse LIVE at the National Exhibition Centre (NEC).
That initial contest in October ended in bizarre fashion as both men fell over the ropes, calling an early end to proceedings in round five as Whittaker suffered an ankle injury during an awkward landing that left him unable to continue as he was escorted from the ring in a wheelchair and later went to hospital for assessment.
Many felt that Cameron had shown more than enough to win on the scorecards in what would have been a sizable upset, though the fight was eventually ruled a split-decision technical draw with one judge scoring it in favour of Cameron, the other for Whittaker and a third having it level.
It meant a surprise end to the early-career winning streak of Whittaker that had stood at eight, though the showboating Olympic silver medalist from Tokyo 2020 did retain the IBF International light-heavyweight title that he won against Eworitse Ezra Arenyeka on the Chris Billam-Smith-Richard Riakporhe undercard at Selhurst Park last summer.
As well as the fallout from that bizarre finish to their first fight, a row over the length of the rematch has led to more hostility in the build-up to an exciting Easter Sunday card that also features the return of Frazer Clarke.
How to watch Whittaker vs Cameron 2
TV channel: Tonight’s event is being shown live on Sky Sports. Coverage starts on Sky Sports Action at 7pm BST and Sky Sports Main Event from 8pm. Ring walks for Whittaker vs Cameron are expected at approximately 10pm.
Live stream: Those with a Sky Sports subscription can also watch the fights live online via the Sky Go app.
Live blog: Standard Sport will also have coverage of every fight this evening via our live blog.