The middle match on Super Saturday sees Steve Borthwick’s side trying to hold up their end of the bargain in the three-way title race after Ireland have battled Italy in Rome and before favourites France tackle Scotland in Paris.
England likely need to win in Cardiff with a bonus point and hope that Les Bleus then slip up later in the evening to win their first Six Nations championship since 2020.
However, Wales have looked mostly much better under Warren Gatland’s interim successor Matt Sherratt, giving back-to-back defending champions Ireland a stern test at home before a spirited second-half fightback against Scotland at Murrayfield in round four saw them ultimately scoop two potentially pivotal bonus points in their battle with Italy to avoid a second successive wooden spoon.
How to watch Wales vs England
TV channel: Wales vs England in the Six Nations is being broadcast live in the UK on BBC One and Welsh-language channel S4C, with coverage starting on both channels at 4pm GMT ahead of a 4:45pm kick-off.
Live stream: The game can also be viewed live online via the BBC Sport website and BBC iPlayer.
Live blog: Follow the match with Standard Sport’s dedicated live blog, featuring expert analysis from Simon Collings at the Principality Stadium.
