Ruben Amorim’s side have lost their last two games and could do with returning to winning ways ahead of Sunday’s huge Manchester derby.
Still, United did at least record a win over Bodo/Glimt in this competition last time out – only their second victory to date.
Strong favourites tonight, the Red Devils need to get back on track.
Here’s everything you need to know about where to watch the game later today.
How to watch Viktoria Plzen vs Manchester United
TV channel: In the UK, the game will be televised live on TNT Sports 2. Coverage starts at 5.30pm GMT ahead of a 5.45pm kick-off.
Live stream: Fans can catch the contest live online via the Discovery+ app and website.
Live blog: You can follow all the action on matchday via Standard Sport’s live blog.