A fortnight of international football brought both good news and bad for Spurs. Randal Kolo Muani returned to the pitch, playing in a behind-closed-doors friendly against Watford, though Yves Bissouma suffered a new setback.
He made his return to the pitch representing Mali, but was injured again moments after coming off the bench against Madagascar and now seems set for another spell on the sidelines.
Unai Emery, meanwhile, is looking to extend Villa’s superb run of form.
After a dismal start to the season, which saw them score just two goals as they failed to win any of their first six matches, the Villans have now won four on the spin.
That leaves them unbeaten in the Europa League and out of the relegation zone.
To upset over third-placed Tottenham in their own backyard would leave them well placed for a midweek trip to face Go Ahead Eagles in Deventer.
How to watch Tottenham vs Aston Villa
TV channel: In the UK, the game will be televised live on Sky Sports Main Event and Sky Sports Premier League, with coverage starting from 1pm BST ahead of a 2pm kick-off.
Live stream: Sky Sports subscribers can also catch the contest live online via the Sky Go app and website.
Live blog: You can follow all the action on matchday via Standard Sport’s live blog, with expert analysis from Matt Verri at the ground.