The Championship side have enjoyed home advantage in the three previous rounds as they dispatched of Charlton, Wycombe and fierce rivals Burnley to book a place in the FA Cup quarter-final.
Meanwhile, this is Villa’s first tie on the road in the competition this season after beating West Ham, Tottenham and lower league opposition in Cardiff at home.
Unai Emery’s side are clear favourites to progress and remain in contention for a remarkable cup double as they have a Champions League quarter-final showdown with Paris Saint-Germain on the horizon.
But can Preston upset the odds to reach the FA Cup semi-final, or will Aston Villa’s Premier League pedigree prove a step too far for Paul Heckingbottom’s side?
Here’s everything you need to know about where to watch…
How to watch Preston vs Aston Villa
TV channel: The game will be broadcast on BBC One which is free to air for UK viewers. Coverage starts at 1.15pm BST ahead of an 1.30pm kick-off.
Live stream: Fans can catch the contest live online via BBC iPlayer and the BBC Sport website.
Live blog: You can follow all the action on matchday via Standard Sport’s live blog.