The Magpies are back in the continent’s top competition after a year away, and have a mouth-watering encounter with the five-time winners first up.
Eddie Howe’s side were knocked out in the group stage two years ago after being drawn in the ‘Group of Death’ alongside Paris Saint-Germain, AC Milan, and Borussia Dortmund, but they made their mark early with a 4-1 drubbing of Paris in the north-east.
They will be hoping for a similar performance this time around as they face Hansi Flick’s La Liga champions, who could be without star man Lamine Yamal, who has been struggling with a groin injury of late.
Newcastle themselves will be without summer signings Yoane Wissa and Jacob Ramsey as both find themselves tied to the treatment table.
Nick Woltemade made a goalscoring start to life on Tyneside as he netted the winner on debut against Wolves last weekend, and he will be hoping to hit the ground running in the Champions League.
Marcus Rashford is likely to make a return to England after leaving Manchester United on loan for Spain in the summer.
How to watch Newcastle vs Barcelona
TV channel: This game will be shown live on TNT Sports 1, with kick off at 8pm BST. Coverage starts at 7pm BST.
Live stream: TNT Sports subscribers can also catch the contest live online via the Discovery+ app and website.
Live blog: You can follow all the action on Wednesday evening via Standard Sport’s dedicated live match blog.