In addition, Ruben Amorim will be without captain Bruno Fernandes and Manuel Ugarte because of suspension, leaving him with a massive dilemma in central midfield.
As for the Magpies, they head to Old Trafford on a great run of form with four straight wins across all competitions, scoring 14 goals in the process and conceding just once.
Where to watch Manchester United vs Newcastle
TV channel: Tonight’s game will be shown live in the UK on Sky Sports Premier League and Sky Sports Main Event, with coverage beginning at 6.30pm GMT. Kick-off at Old Trafford is at 8pm.
Live stream: Fans can catch the contest live online via the Sky Go app and website.
Live blog: You can follow all the action on matchday via Standard Sport’s live blog.