Having been knocked out of the FA Cup and Carabao Cup, while languishing in the bottom half of the Premier League table, only lifting the European trophy in May will prevent the campaign going down as the club’s worst in modern history.
Lyon will likely prove to be no pushovers, especially for a team like United who struggle in front of goal, but the Ligue 1 side’s leaky defence is a place for Ruben Amorim’s side to exploit.
The game developed an extra spice the day before kick-off as Andre Onana and Nemanja Matic, formerly of United, traded blows. After the goalkeeper had confidently claimed United were “way better” than Lyon, Matic hit back by claiming Onana was the “worst keeper in United’s history” in an eye-widening takedown.
How to watch Lyon vs Manchester United
TV channel: In the UK, the game will be televised live on TNT Sports 1. Coverage starts at 7.45pm BST ahead of an 8pm kick-off.
Live stream: TNT Sports subscribers can also catch the contest live online via the Discovery+ app and website.
Live blog: You can follow all the action on matchday via Standard Sport’s live blog, with expert analysis from Dan Kilpatrick at the ground.