The two teams are separated by just a point heading into the final round of fixtures and will both hope to avoid a two-legged play-off next month by ensuring they finish in the top eight.
United could certainly do with a boost given how poor the results have been under Ruben Amorim, albeit the Romanian outfit – formerly known as Steaua Bucharest – will fancy their chances.
Here’s everything you need to know about where to watch the game.
How to watch FCSB vs Manchester United
TV channel: In the UK, the game will be televised live on TNT Sports 1. Coverage starts at 7pm GMT ahead of an 8pm kick-off.
Live stream: Fans can catch the contest live online via the Discovery+ app and website.
Live blog: You can follow all the action on matchday via Standard Sport’s live blog.