The Scot was named by the Red Devils as the initial caretaker manager, while United search for a more permanent solution.
Now, he will lead United for the first time at Burnley, looking to get the club back to winning ways after disappointing draws against Wolves and Leeds.
Burnley, meanwhile, are entrenched in a relegation dogfight, mired in the drop zone.
Scott Parker’s side are 19th, on 12 points, and they are nine points from safety.
How to watch Burnley vs Man Utd
TV channel: In the UK, the game will be televised live on Sky Sports. Coverage starts at 6pm GMT on Sky Sports Premier League ahead of kick-off at 8.15pm.
Live stream: Sky Sports subscribers can also catch the contest live online via the Sky Go app.
Live blog: You can follow all the action on matchday via Standard Sport’s live blog!
