Pictures have been sent in showing what is left of the herd in Romilly Road, Finsbury Park.
Two of the four topiary elephants have come under attack by an invasive disease known as honey fungus.
The fungus is a largely hidden killer, spreading underground and destroying the roots of plants before attacking the dead wood.
The artist behind the herd, Islington-based Tim Bushe, has been documenting his attempt to save the remaining two elephants from the same fate on Instagram.
Dead growth killed by the honey fungus can clearly seen on one of four elephants in Romilly Road, in Finsbury Park (Image: David Winskill)
He wrote on April 21: “Disaster … Honey Fungus has taken out elephant number three.
“We are going to take the dead section out and replant with another species hoping we can save it.”
The artist behind the herd Tim Bushe is attempting to salvage the remaining two elephants from the same disease (Image: David Winskill)
Crouch End campaigner David Winskill told the Ham & High: “This is such a great pity.
“Finsbury Park’s little herd of elephants has been a landmark and raising smiles for years.
“I do hope Mr Bushe’s remedial action is successful and he can continue creating these brilliant sculptures.”